Prof. Zheng Liu obtained his bachelor's, master's and doctoral degrees in chemical engineering from Tsinghua University in 1987, 1989 and 1993, respectively. He worked as a UNESCO Research Fellow at Tokyo Institute of Technology, Japan, during 1993 to 1994 and served as a Professor at department of chemical engineering, Tsinghua University since 1998. His current research focuses on chemical and biomolecular engineering with special interests in 1) AI assisted molecular and process engineering of industrial enzymes; 2) electric field intensified enzymatic processes and 3) novel prebiotics, and has resulted in 200 peer-reviewed journal papers. He has supervised over 50 graduate students, one of which received the National Best PhD Dissertation Award in 2008. Prof. Liu was awarded as Chang Jiang Scholars Professor of biochemical engineering, Ministry of Education, in 2012.

1. Han, Y.L., Zhang, H.Y., Zeng, Z.N., Liu, Z.Y., Lu, D.N.*, & Liu, Z.* (2024). Descriptor-augmented machine learning for enzyme-chemical interaction predictions. Synthetic and Systems Biotechnology, 9, 259-268. https://doi.org/10.1016/j.synbio.2024.02.006

2. Jian, Y.P. Zhu, K.Y., Han, Y.L., Zhang, S.W., Xia, M., Jiang, G.Q., & Liu, Z.*(2024), Boosting Enzyme Activity in an Anhydrous Gas Flux with Amphiphilic Polymers. ChemCatChem, 17, https://doi.org/10.1002/cctc.202401509

3. Zhuang, H., Yang, Z., Chen, T., Jing, N., Zhou, Y., Jiang, G.*, Wang, Y., Wang, Z., & Liu, Z.* (2023). Boosting HSA Vaccination with Jujube Powder Modulating Gut Microbiota Favorable for Arginine Metabolism. Nutrients, 15(8), Article 1955. https://doi.org/10.3390/nu15081955

4. Jian, Y. P., Han, Y. L., Fu, Z. W., Xia, M., Jiang, G. Q., Lu, D. N., Wu, J. Z., & Liu, Z.* (2022). The role of conformational dynamics in the activity of polymer-conjugated CalB in organic solvents. Physical Chemistry Chemical Physics, 24(36), 22028-22037. https://doi.org/10.1039/d2cp02208g

5. Jing, N., Wang, L., Zhuang, H., Jiang, G.*, & Liu, Z.* (2021). Ultrafine Jujube Powder Enhances the Infiltration of Immune Cells during Anti-PD-L1 Treatment against Murine Colon Adenocarcinoma. Cancers, 13(16), Article 3987. https://doi.org/10.3390/cancers13163987

6. Zhuang, H., Jing, N., Wang, L., Jiang, G.*, & Liu, Z. (2021). Jujube Powder Enhances Cyclophosphamide Efficiency against Murine Colon Cancer by Enriching CD8+ T Cells While Inhibiting Eosinophilia . Nutrients, 13(8), Article 2700. https://doi.org/10.3390/nu13082700

7. Liu, X. R., Wang, L. Y.*, Jing, N., Jiang, G. Q., & Liu, Z.* (2020). Biostimulating Gut Microbiome with Bilberry Anthocyanin Combo to Enhance Anti-PD-L1 Efficiency against Murine Colon Cancer. Microorganisms, 8(2), Article 175. https://doi.org/10.3390/microorganisms8020175

8. Fu, Z. W., Xu, W. N., Chen, G., Wang, Z. Y., Lu, D. N.*, Wu, J. Z.*, & Liu, Z.* (2019). Molecular dynamics simulations reveal how graphene oxide stabilizes and activates lipase in an anhydrous gas. Physical Chemistry Chemical Physics, 21(45), 25425-25430. https://doi.org/10.1039/c9cp05271b

9. Xu, W. N., Fu, Z. W., Chen, G., Wang, Z. Y., Jian, Y. P., Zhang, Y. F., Jiang, G. Q., Lu, D. N., Wu, J. Z., & Liu, Z.* (2019). Graphene oxide enabled long-term enzymatic transesterification in an anhydrous gas flux. Nature Communications, 10, Article 2684. https://doi.org/10.1038/s41467-019-10686-z

10. Chen, G., Xu, W. N., Lu, D. N.*, Wu, J. Z.*, & Liu, Z.* (2018). Markov-state model for CO2 binding with carbonic anhydrase under confinement. Journal of Chemical Physics, 148(3), Article 035101. https://doi.org/10.1063/1.5003298

11. Chen, G., Kong, X. A., Lu, D. N.*, Wu, J. Z.*, & Liu, Z.* (2017). Kinetics of CO2 diffusion in human carbonic anhydrase: a study using molecular dynamics simulations and the Markov-state model. Physical Chemistry Chemical Physics, 19(18), 11690-11697. https://doi.org/10.1039/c7cp00887b

12. Xu, W. N., Yong, Y., Wang, Z. Y., Jiang, G. Q., Wu, J. Z., & Liu, Z.* (2017). Concanavalin A Coated Activated Carbon for High Performance Enzymatic Catalysis. ACS Sustainable Chemistry & Engineering, 5(1), 90-96. https://doi.org/10.1021/acssuschemeng.6b02705

13. Kong, X., Lu, D. N.*, Wu, J. Z.*, & Liu, Z.*(2016). Spreading of a Unilamellar Liposome on Charged Substrates: A Coarse-Grained Molecular Simulation. Langmuir, 32(15), 3785-3793. https://doi.org/10.1021/acs.langmuir.6b00043

14. Kong, X., Lu, D. N.*, Liu, Z.*, & Wu, J. Z.* (2015). Molecular dynamics for the charging behavior of nano-structured electric double layer capacitors containing room temperature ionic liquids. Nano Research, 8(3), 931-940. https://doi.org/10.1007/s12274-014-0574-0

15. Ren, L. W., Wang, Y. S., Ge, J., Lu, D. N.*, & Liu, Z.* (2015). Enzymatic Synthesis of High-Molecular-Weight Poly(butylene succinate) and its Copolymers. Macromolecular Chemistry and Physics, 216(6), 636-640. https://doi.org/10.1002/macp.201400550

16. Zhang, Y. F., Ge, J.*, & Liu, Z.* (2015). Enhanced Activity of Immobilized or Chemically Modified Enzymes. ACS Catalysis, 5(8), 4503-4513. https://doi.org/10.1021/acscatal.5b00996

17. Kong, X., Qin, S. S., Lu, D. N.*, & Liu, Z.* (2014). Surface tension effects on the phase transition of a DPPC bilayer with and without protein: a molecular dynamics simulation. Physical Chemistry Chemical Physics, 16(18), 8434-8440. https://doi.org/10.1039/c3cp55524k

18. Lyu, F. J., Zhang, Y. F., Zare, R. N., Ge, J.*, & Liu, Z.* (2014). One-Pot Synthesis of Protein-Embedded Metal-Organic Frameworks with Enhanced Biological Activities. Nano Letters, 14(10), 5761-5765. https://doi.org/10.1021/nl5026419

19. Wu, B. B., Lan, T., Lu, D. N.*, & Liu, Z.* (2014). Ecological and enzymatic responses to petroleum contamination. Environmental Science-Processes & Impacts, 16(6), 1501-1509.

20. Wang, R., Zhang, Y. F., Huang, J. H., Lu, D. N., Ge, J.*, & Liu, Z.* (2013). Substrate imprinted lipase nanogel for one-step synthesis of chloramphenicol palmitate. Green Chemistry, 15(5), 1155-1158. https://doi.org/10.1039/c3gc40465j

21. Zhu, J. Y., Zhang, Y. F., Lu, D. N., Zare, R. N., Ge, J.*, & Liu, Z.* (2013). Temperature-responsive enzyme-polymer nanoconjugates with enhanced catalytic activities in organic media. Chemical Communications, 49(54), 6090-6092. https://doi.org/10.1039/c3cc42493f

22. Lin, M., Lu, D., Zhu, J., Yang, C., Zhang, Y., & Liu, Z.* (2012). Magnetic enzyme nanogel (MENG): a universal synthetic route for biocatalysts. Chemical Communications, 48(27), 3315-3317. https://doi.org/10.1039/c2cc30189j

23. Lin, S., Wang, G., Na, Z., Lu, D.*, & Liu, Z.* (2012). Long-root Eichhornia crassipes as a biodegradable adsorbent for aqueous As(III) and As(V). Chemical Engineering Journal, 183, 365-371. https://doi.org/10.1016/j.cej.2012.01.013

24. Lu, D., Yang, C., & Liu, Z.* (2012). How Hydrophobicity and the Glycosylation Site of Glycans Affect Protein Folding and Stability: A Molecular Dynamics Simulation. Journal of Physical Chemistry B, 116(1), 390-400. https://doi.org/10.1021/jp203926r

25. Sen, L., Diannan, L.*, & Zheng, L.* (2012). Removal of arsenic contaminants with magnetic y-Fe2O3nanoparticles. Chemical Engineering Journal, 211-212, 46-52. https://doi.org/10.1016/j.cej.2012.09.018

26. Xu, D., Tonggu, L., Bao, X., Lu, D.*, & Liu, Z.* (2012). Activation and stabilization of a lipase nanogel using GMA for acryloylation. Soft Matter, 8(6), 2036-2042. https://doi.org/10.1039/c1sm06853a

27. Liu, Z. X., Lu, D. N., Yin, L., Li, J. M., Cui, Y. C., Chen, W.*, & Liu, Z.* (2011). Strengthening the Stability of a Tunnel-Shaped Homotetramer Protein with Nanogels. Journal of Physical Chemistry B, 115(28), 8875-8882. https://doi.org/10.1021/jp108941f

28. Wu, Z. J., Dong, H. J., Zou, L. D., Lu, D. N., & Liu, Z.* (2011). Enriched Microbial Community in Bioaugmentation of Petroleum-Contaminated Soil in the Presence of Wheat Straw. Applied Biochemistry and Biotechnology, 164(7), 1071-1082. https://doi.org/10.1007/s12010-011-9195-1

29. Yang, C., Lu, D. N., & Liu, Z.* (2011). How PEGylation Enhances the Stability and Potency of Insulin: A Molecular Dynamics Simulation. Biochemistry, 50(13), 2585-2593. https://doi.org/10.1021/bi101926u

30. Zhu, B. B., Lu, D. N., Ge, J., & Liu, Z.* (2011). Uniform polymer-protein conjugate by aqueous AGET ATRP using protein as a macroinitiator. Acta Biomaterialia, 7(5), 2131-2138.