Dr. Lei Qin obtained his bachelor's, master's, and doctoral degrees from the School of Chemical Engineering at Tianjin University in 2009, 2012 and 2017, respectively. During the doctoral studies, he was awarded national scholarships for two consecutive years. From November 2017 to December 2022, he worked as a postdoctoral researcher at the School of Chemistry and Chemical Engineering at Beijing Institute of Technology and the Department of Chemical Engineering at Tsinghua University. Since March 2023, he has been hired as an assistant researcher by the Department of Chemical Engineering at Tsinghua University, mainly engaged in system design of industrial microbial stress resistance and robustness, construction of microbial resistance network model, and application of synthetic biology to construct intelligent and robust chassis cells for the synthesis of biofuels and other products, improving the green and economic efficiency of biological manufacturing. He has published more than 30 SCI papers in major journals in the field of biochemical engineering, such as Metab Eng, ACS Energy Lett, and Bioresour Technol, obtained 8 invention patents, and led projects funded including the National Natural Science Foundation and National Key Research and Development Program. The transformed stress resistant yeast strain has achieved performance transformation in the enterprise.

2005~2009 Bachelor of Engineering, Department of Chemical Engineering, Tianjin University

2009~2012 Master of Engineering, Department of Chemical Engineering, Tianjin University

2012~2013 Research Assistant, Tianjin University

2013~2017 Ph.D., Department of Chemical Engineering, Tianjin University

2017~2020 Postdoctoral Scholar, Department of Chemistry and Chemical Engineering, Beijing Institute of Technology

2020~2022 Postdoctoral Scholar, Department of Chemical Engineering, Tsinghua University

2023~present Assistant Researcher, Department of Chemical Engineering, Tsinghua University

Stress-resistance design and engineering application of industrial microorganisms

High version chassis cell design

Microbial synthesis of plant natural products

1. Zhang Y, Ma Z, Li W, Liu C, Gao H, Wang Meng, Li L, Zhang Q, Lv B*, Qin L*, Li C*. Dynamic regulation and enhancement of synthetic network for efficient biosynthesis of monoterpenoid α-pinene in yeast cell factory. Bioresource Technology 2025, 12:132064.

2. Xiang L, Sun W, Zhang S, Zhang H, Lv B*, Qin L*, Li C*. Discovery, Biomanufacture and Derivatization of Licorice Triterpenoids. Journal of Agriculture and Food Chemistry 2025, 73(1):4-29.

3. Qin L, Ma D, Lin G, Sun W, Li C. Low temperature promotes the production and efflux of terpenoids in yeast. Bioresource Technology 2024, 24:130376.

4. Liu X^#, Qin L^#, Yu J, Sun W, Xu J, Li C*. Real-time monitoring of subcellular states with genetically encoded redox biosensor system (RBS) in yeast cell factories. Biosensors and Bioelectronics 2023, 222:114988.

5. Qin L, Liu X, Xu K, Li C*. Mining and design of biosensors for engineering microbial cell factory. Current Opinions in Biotechnology 2022, 75:102694.

6. Gao X, Xu K, Ahmad N, Qin L*, Li C. Recent advances in engineering of microbial cell factories for intelligent pH regulation and tolerance. Biotechnology Journal 2021, 24:e2100151.

7. Qin L, Dong S, Yu J, Ning X, Xu K, Zhang SJ, Xu L, Li BZ, Li J, Yuan YJ, Li C*. Stress-driven dynamic regulation of multiple tolerance genes improves robustness and productive capacity of Saccharomyces cerevisiae in industrial lignocellulose fermentation. Metabolic Engineering 2020, 61:160-170.

8. Xu K^#, Qin L^#, Bai W, Wang X, Li F, Ren S, Gao X, Chen B, Tong Y, Li J, Li BZ, Yuan YJ, Li C*. Multilevel defense system (MDS) relieves multiple stresses for economically boosting ethanol production of industrial Saccharomyces cerevisiae. ACS Energy Letters 2020, 5:572-582.

9. Qin L, Li WC, Zhu JQ, Liang JN, Li BZ*, Yuan YJ. Ethylenediamine pretreatment changes cellulose allomorph and lignin structure of lignocellulose at ambient pressure. Biotechnology for Biofuels 2015, 8:174.

10. Liu ZH^#, Qin L^#, Li BZ*, Yuan YJ. Physical and chemical characterization of corn stover from leading pretreatment methods and effects on enzymatic hydrolysis. ACS Sustainable Chemistry and Engineering 2015, 3:140-6.

11. Qin L, Liu ZH, Jin M, Li BZ, Yuan YJ*. High temperature aqueous ammonia pretreatment and post-washing enhance the high solids enzymatic hydrolysis of corn stover. Bioresource Technology 2013, 146:504-11.

12. Qin L, Liu ZH, Li BZ, Dale BE, Yuan YJ*. Mass balance and transformation of corn stover by pretreatment with different dilute organic acids. Bioresource Technology 2012, 112:319-26.

13. Qin L, Li WC, Zhu JQ, Li BZ*, Yuan YJ. Chapter 1. Hydrolysis of Lignocellulosic Biomass to Sugars. In: Fang Z., Smith, Jr. R., Qi X. (eds) Production of Platform Chemicals from Sustainable Resources. Biofuels and Biorefineries. 2017. Springer Nature Singapore.