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张翀    副教授


电话:010-62788816
地址:清华大学工物馆
邮件:chongzhang@tsinghua.edu.cn



致力于面向微生物智能制造,开展高通量基因型-表型关联原创技术与装备的研究,包括微生物工业表型高通量表征与连续进化,全基因组规模基因及位点功能挖掘,基因型与工业表型关联研究装备等。在Nature Chemical Biology,Nature Communications, Nucleic Acid Research, Metabolic Engineering,ACS Synthetic Biology,Biotechnology and Bioengineering等刊物发表SCI收录论文近100篇。所持有的20余项专利中有5项通过授权实施许可实现产业化,创造了良好的经济效益。主持制定5项微生物育种共性技术国家标准。主持国家自然科学基金重点、面上、青年项目4项,国家重点研发计划课题2项等国家和企业合作课题10余项。

●  教育与工作经历

1998~2002     清华大学化学工程系    本科

2002~2008     清华大学化学工程系    博士

2008~2010     清华大学化学工程系    博士后

2010~2011     清华大学化学工程系    助理研究员

2011~至今     清华大学化学工程系    副教授

●  研究领域

系统与合成生物学、代谢工程、微生物育种技术与装备

●  开设课程及编写教材

《生物化工基础》(本科生必修)

《合成生物学前沿研讨》(研究生选修)

《现代生命科学与工程前沿》(研究生选修、英文授课、清华-东工大联合培养双硕士项目)

●  主要学术任职

担任Journal of Bioscience Bioengineering,BMC Biotechnology、Engineering Biology、合成生物学等期刊编委,中国生物发酵产业协会生物育种分会秘书长,中国医药生物技术协会合成生物技术分会委员。

●  代表性论文/专利/著作

1.Feng, H., Guo, J., Wang, T., Zhang, C.*, & Xing, X.-H. Guide-target mismatch effects on dCas9–sgRNA binding activity in living bacterial cells, Nucleic Acids Research 49, 3, 1263–1277, (2021)

2.Wang, T.*, Zheng, X., Ji, H., Wang, T. L., Xing, X. H., & Zhang, C.*. Dynamics of transcription–translation coordination tune bacterial indole signaling. Nature Chemical Biology 16, 440–449, (2020)

3.Jian, X., Guo, X., Wang, J., Tan, Z.L., Xing, X. H., Wang, L. Y.*, Zhang, C.*. Microbial microdroplet culture system (MMC): an integrated platform for automated, high–throughput microbial cultivation and adaptive evolution. Biotechnology and Bioengineering 117, 6, 1724-1737 (2020)

4.Wang, T., Guan, C., Guo, J., Liu, B., Wu, Y., Xie, Z., Zhang, C.* & Xing, X.-H. Pooled CRISPR interference screening enables genome-scale functional genomics study in bacteria with superior performance. Nature Communications 9, 2475 (2018).

5.Guo, J., Wang, T., Guan, C., Liu, B., Luo, C., Xie, Z., Zhang, C.* & Xing, X.-H. Improved sgRNA design in bacteria via genome-wide activity profiling. Nucleic Acids Research 46, 7052-7069, (2018).

6.Zhou, Y., Li, G., Dong, J., Xing, X.-H., Dai, J.* & Zhang, C.*. MiYA, an efficient machine-learning workflow in conjunction with the YeastFab assembly strategy for combinatorial optimization of heterologous metabolic pathways in Saccharomyces cerevisiae. Metabolic Engineering 47, 294-302, (2018).

7.Liang, W.-F., Cui, L.-Y., Cui, J.-Y., Yu, K.-W., Yang, S., Wang, T.-M., Guan, C.-G., Zhang, C.* & Xing, X.-H. Biosensor-assisted transcriptional regulator engineering for Methylobacterium extorquens AM1 to improve mevalonate synthesis by increasing the acetyl-CoA supply. Metabolic Engineering 39, 159-168 (2017).

8.Liu, S.-D., Wu, Y.-N., Wang, T.-M., Zhang, C.*. & Xing, X.-H. Maltose Utilization as a Novel Selection Strategy for Continuous Evolution of Microbes with Enhanced Metabolite Production. ACS Synthetic Biology 6, 2326-2338, (2017).

9.Fang, M., Wang, T., Zhang, C.*, Bai, J., Zheng, X., Zhao, X., Lou, C. & Xing, X.-H. Intermediate-sensor assisted push-pull strategy and its application in heterologous deoxyviolacein production in Escherichia coli. Metabolic Engineering 33, 41-51, (2016).

●  学术荣誉与奖励

亚洲生物技术青年科学家奖(日本生物工学会,2020)

中国轻工业联合会技术发明一等奖(2019)

教育部高层次青年人才计划(2018)

伦世仪教育基金会发酵工程杰出青年学者奖(2018)

日内瓦国际发明博览会金奖(2017)

清华大学教育教学成果一等奖(2016)







地址:北京市海淀区清华园化工系工物馆   邮编:100084
Email:chemeng@tsinghua.edu.cn

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