主要从事工业微生物抗逆性和鲁棒性的系统设计，构建微生物抗逆网络模型，运用合成生物学构建智能鲁棒底盘细胞用于生物燃料等产品合成，提高生物制造的绿色性与经济性。在Metab Eng、ACS Energy Let、Bioresour Technol等生物化工领域重要期刊发表SCI论文40余篇，授权发明专利8项，主持国家自然科学基金、重点研发计划课题等项目，改造的抗逆酵母菌株在企业实现成果转化。
2009年、2012年和2017年分别在天津大学化工学院获学士、硕士和博士学位，博士期间连续两年获国家奖学金。2017年11月至2022年12月分别在北京理工大学化学与化工学院、清华大学化工系从事博士后研究工作。自2023年3月，被清华大学化工系聘为助理研究员留校工作。主要从事工业微生物抗逆性和鲁棒性的系统设计，构建微生物抗逆网络模型，运用合成生物学构建智能鲁棒底盘细胞用于生物燃料等产品合成，提高生物制造的绿色性与经济性。在Metab Eng、ACS Energy Lett、Bioresour Technol等生物化工领域重要期刊发表SCI论文40余篇，授权发明专利8项，主持国家自然科学基金、重点研发计划课题等项目，改造的抗逆酵母菌株在企业实现成果转化。
Dr. Lei Qin obtained his bachelor's, master's, and doctoral degrees from the School of Chemical Engineering at Tianjin University in 2009, 2012 and 2017, respectively. During the doctoral studies, he was awarded national scholarships for two consecutive years. From November 2017 to December 2022, he worked as a postdoctoral researcher at the School of Chemistry and Chemical Engineering at Beijing Institute of Technology and the Department of Chemical Engineering at Tsinghua University. Since March 2023, he has been hired as an assistant researcher by the Department of Chemical Engineering at Tsinghua University, mainly engaged in system design of industrial microbial stress resistance and robustness, construction of microbial resistance network model, and application of synthetic biology to construct intelligent and robust chassis cells for the synthesis of biofuels and other products, improving the green and economic efficiency of biological manufacturing. He has published more than 30 SCI papers in major journals in the field of biochemical engineering, such as Metab Eng, ACS Energy Lett, and Bioresour Technol, obtained 8 invention patents, and led projects funded including the National Natural Science Foundation and National Key Research and Development Program. The transformed stress resistant yeast strain has achieved performance transformation in the enterprise.
● 教育与工作经历
2005年9月~ 2009年6月 天津大学 生物工程 学士
2009年9月~ 2012年6月 天津大学 生物化工 硕士
2012年7月~ 2013年8月 天津大学 科研助理
2013年9月~ 2017年6月 天津大学 生物化工 博士
2017年10月~ 2020年11月 北京理工大学 博士后
2020年12月~ 2022年12月 清华大学化工系 博士后
2023年3月~ 至今 清华大学化工系 助理研究员
2005~2009 Bachelor of Engineering, Department of Chemical Engineering, Tianjin University
2009~2012 Master of Engineering, Department of Chemical Engineering, Tianjin University
2012~2013 Research Assistant, Tianjin University
2013~2017 Ph.D., Department of Chemical Engineering, Tianjin University
2017~2020 Postdoctoral Scholar, Department of Chemistry and Chemical Engineering, Beijing Institute of Technology
2020~2022 Postdoctoral Scholar, Department of Chemical Engineering, Tsinghua University
2023~present Assistant Researcher, Department of Chemical Engineering, Tsinghua University
● 研究领域
工业微生物的抗逆设计与工程应用、高版本鲁棒性底盘细胞设计、植物天然产物的微生物合成
Stress-resistance design and engineering application of industrial microorganisms
High version chassis cell design
Microbial synthesis of plant natural products
● 代表性论文/专利/专著
1. Zhang Y, Ma Z, Li W, Liu C, Gao H, Wang Meng, Li L, Zhang Q, Lv B*, Qin L*, Li C*. Dynamic regulation and enhancement of synthetic network for efficient biosynthesis of monoterpenoid α-pinene in yeast cell factory. Bioresource Technology 2025, 12:132064.
2. Xiang L, Sun W, Zhang S, Zhang H, Lv B*, Qin L*, Li C*. Discovery, Biomanufacture and Derivatization of Licorice Triterpenoids. Journal of Agriculture and Food Chemistry 2025, 73(1):4-29.
3. Qin L, Ma D, Lin G, Sun W, Li C. Low temperature promotes the production and efflux of terpenoids in yeast. Bioresource Technology 2024, 24:130376.
4. Liu X#, Qin L#, Yu J, Sun W, Xu J, Li C*. Real-time monitoring of subcellular states with genetically encoded redox biosensor system (RBS) in yeast cell factories. Biosensors and Bioelectronics 2023, 222:114988.
5. Qin L, Liu X, Xu K, Li C*. Mining and design of biosensors for engineering microbial cell factory. Current Opinions in Biotechnology 2022, 75:102694.
6. Gao X, Xu K, Ahmad N, Qin L*, Li C. Recent advances in engineering of microbial cell factories for intelligent pH regulation and tolerance. Biotechnology Journal 2021, 24:e2100151.
7. Qin L, Dong S, Yu J, Ning X, Xu K, Zhang SJ, Xu L, Li BZ, Li J, Yuan YJ, Li C*. Stress-driven dynamic regulation of multiple tolerance genes improves robustness and productive capacity of Saccharomyces cerevisiae in industrial lignocellulose fermentation. Metabolic Engineering 2020, 61:160-170.
8. Xu K#, Qin L#, Bai W, Wang X, Li F, Ren S, Gao X, Chen B, Tong Y, Li J, Li BZ, Yuan YJ, Li C*. Multilevel defense system (MDS) relieves multiple stresses for economically boosting ethanol production of industrial Saccharomyces cerevisiae. ACS Energy Letters 2020, 5:572-582.
9. Qin L, Li WC, Zhu JQ, Liang JN, Li BZ*, Yuan YJ. Ethylenediamine pretreatment changes cellulose allomorph and lignin structure of lignocellulose at ambient pressure. Biotechnology for Biofuels 2015, 8:174.
10. Liu ZH#, Qin L#, Li BZ*, Yuan YJ. Physical and chemical characterization of corn stover from leading pretreatment methods and effects on enzymatic hydrolysis. ACS Sustainable Chemistry and Engineering 2015, 3:140-6.
11. Qin L, Liu ZH, Jin M, Li BZ, Yuan YJ*. High temperature aqueous ammonia pretreatment and post-washing enhance the high solids enzymatic hydrolysis of corn stover. Bioresource Technology 2013, 146:504-11.
12. Qin L, Liu ZH, Li BZ, Dale BE, Yuan YJ*. Mass balance and transformation of corn stover by pretreatment with different dilute organic acids. Bioresource Technology 2012, 112:319-26.
13. Qin L, Li WC, Zhu JQ, Li BZ*, Yuan YJ. Chapter 1. Hydrolysis of Lignocellulosic Biomass to Sugars. In: Fang Z., Smith, Jr. R., Qi X. (eds) Production of Platform Chemicals from Sustainable Resources. Biofuels and Biorefineries. 2017. Springer Nature Singapore.
