主要从事生物化工领域的教学和研究工作，主要内容包括蛋白质构象转换调控及其在蛋白质折叠和分离中的应用，纳米酶制剂及其在工业催化中的应用以及土壤生物修复技术等。发表论文190余篇，其中SCI收录 120余篇，专利授权10项。已培养研究生逾50名，其中全国优秀百篇博士论文1人。先后获清华大学研究生良师益友奖（2004，2018，2020），获得全国高等学校优秀骨干教师奖（2002），教育部新世纪优秀人才支持计划（2004），国务院政府特殊津贴（2007），宝钢优秀教师（2016）。

● 教育与工作经历

1982~1987 清华大学化学工程系 本科

1987~1989 清华大学化学工程系 硕士

1989~1993 清华大学化学工程系 博士

1993~1994 日本东京工业大学 访问学者

1993~1996 清华大学化学工程系 讲师

1996~1998 清华大学化学工程系 副教授

1998~至今 清华大学化学工程系 教授

● 研究领域

蛋白质构象转换调控及其在蛋白质折叠和分离中的应用；纳米酶制剂及其在工业催化中的应用；土壤生物修复。

● 开设课程及编写教材

清华大学本科生《分子设计与化学工程》

清华大学研究生《生物分离工程》（英文）

● 主要学术任职

2018年~至今 教育部化工类教学指导委员会 委员

2021年~至今 国务院学位办化学工程与技术分委员委员

2012年~至今 中国化工学会生物化工专业委员会 副主任

2012年~至今 工业生物催化教育部重点实验室 主任

● 代表性论文/专利/著作

1. Han, Y.L., Zhang, H.Y., Zeng, Z.N., Liu, Z.Y., Lu, D.N.*, & Liu, Z.* (2024). Descriptor-augmented machine learning for enzyme-chemical interaction predictions. Synthetic and Systems Biotechnology, 9, 259-268. https://doi.org/10.1016/j.synbio.2024.02.006

2. Jian, Y.P. Zhu, K.Y., Han, Y.L., Zhang, S.W., Xia, M., Jiang, G.Q., & Liu, Z.*(2024), Boosting Enzyme Activity in an Anhydrous Gas Flux with Amphiphilic Polymers. ChemCatChem, 17, https://doi.org/10.1002/cctc.202401509

3. Zhuang, H., Yang, Z., Chen, T., Jing, N., Zhou, Y., Jiang, G.*, Wang, Y., Wang, Z., & Liu, Z.* (2023). Boosting HSA Vaccination with Jujube Powder Modulating Gut Microbiota Favorable for Arginine Metabolism. Nutrients, 15(8), Article 1955. https://doi.org/10.3390/nu15081955

4. Jian, Y. P., Han, Y. L., Fu, Z. W., Xia, M., Jiang, G. Q., Lu, D. N., Wu, J. Z., & Liu, Z.* (2022). The role of conformational dynamics in the activity of polymer-conjugated CalB in organic solvents. Physical Chemistry Chemical Physics, 24(36), 22028-22037. https://doi.org/10.1039/d2cp02208g

5. Jing, N., Wang, L., Zhuang, H., Jiang, G.*, & Liu, Z.* (2021). Ultrafine Jujube Powder Enhances the Infiltration of Immune Cells during Anti-PD-L1 Treatment against Murine Colon Adenocarcinoma. Cancers, 13(16), Article 3987. https://doi.org/10.3390/cancers13163987

6. Zhuang, H., Jing, N., Wang, L., Jiang, G.*, & Liu, Z. (2021). Jujube Powder Enhances Cyclophosphamide Efficiency against Murine Colon Cancer by Enriching CD8+ T Cells While Inhibiting Eosinophilia . Nutrients, 13(8), Article 2700. https://doi.org/10.3390/nu13082700

7. Liu, X. R., Wang, L. Y.*, Jing, N., Jiang, G. Q., & Liu, Z.* (2020). Biostimulating Gut Microbiome with Bilberry Anthocyanin Combo to Enhance Anti-PD-L1 Efficiency against Murine Colon Cancer. Microorganisms, 8(2), Article 175. https://doi.org/10.3390/microorganisms8020175

8. Fu, Z. W., Xu, W. N., Chen, G., Wang, Z. Y., Lu, D. N.*, Wu, J. Z.*, & Liu, Z.* (2019). Molecular dynamics simulations reveal how graphene oxide stabilizes and activates lipase in an anhydrous gas. Physical Chemistry Chemical Physics, 21(45), 25425-25430. https://doi.org/10.1039/c9cp05271b

9. Xu, W. N., Fu, Z. W., Chen, G., Wang, Z. Y., Jian, Y. P., Zhang, Y. F., Jiang, G. Q., Lu, D. N., Wu, J. Z., & Liu, Z.* (2019). Graphene oxide enabled long-term enzymatic transesterification in an anhydrous gas flux. Nature Communications, 10, Article 2684. https://doi.org/10.1038/s41467-019-10686-z

10. Chen, G., Xu, W. N., Lu, D. N.*, Wu, J. Z.*, & Liu, Z.* (2018). Markov-state model for CO2 binding with carbonic anhydrase under confinement. Journal of Chemical Physics, 148(3), Article 035101. https://doi.org/10.1063/1.5003298

11. Chen, G., Kong, X. A., Lu, D. N.*, Wu, J. Z.*, & Liu, Z.* (2017). Kinetics of CO2 diffusion in human carbonic anhydrase: a study using molecular dynamics simulations and the Markov-state model. Physical Chemistry Chemical Physics, 19(18), 11690-11697. https://doi.org/10.1039/c7cp00887b

12. Xu, W. N., Yong, Y., Wang, Z. Y., Jiang, G. Q., Wu, J. Z., & Liu, Z.* (2017). Concanavalin A Coated Activated Carbon for High Performance Enzymatic Catalysis. ACS Sustainable Chemistry & Engineering, 5(1), 90-96. https://doi.org/10.1021/acssuschemeng.6b02705

13. Kong, X., Lu, D. N.*, Wu, J. Z.*, & Liu, Z.*(2016). Spreading of a Unilamellar Liposome on Charged Substrates: A Coarse-Grained Molecular Simulation. Langmuir, 32(15), 3785-3793. https://doi.org/10.1021/acs.langmuir.6b00043

14. Kong, X., Lu, D. N.*, Liu, Z.*, & Wu, J. Z.* (2015). Molecular dynamics for the charging behavior of nano-structured electric double layer capacitors containing room temperature ionic liquids. Nano Research, 8(3), 931-940. https://doi.org/10.1007/s12274-014-0574-0

15. Ren, L. W., Wang, Y. S., Ge, J., Lu, D. N.*, & Liu, Z.* (2015). Enzymatic Synthesis of High-Molecular-Weight Poly(butylene succinate) and its Copolymers. Macromolecular Chemistry and Physics, 216(6), 636-640. https://doi.org/10.1002/macp.201400550

16. Zhang, Y. F., Ge, J.*, & Liu, Z.* (2015). Enhanced Activity of Immobilized or Chemically Modified Enzymes. ACS Catalysis, 5(8), 4503-4513. https://doi.org/10.1021/acscatal.5b00996

17. Kong, X., Qin, S. S., Lu, D. N.*, & Liu, Z.* (2014). Surface tension effects on the phase transition of a DPPC bilayer with and without protein: a molecular dynamics simulation. Physical Chemistry Chemical Physics, 16(18), 8434-8440. https://doi.org/10.1039/c3cp55524k

18. Lyu, F. J., Zhang, Y. F., Zare, R. N., Ge, J.*, & Liu, Z.* (2014). One-Pot Synthesis of Protein-Embedded Metal-Organic Frameworks with Enhanced Biological Activities. Nano Letters, 14(10), 5761-5765. https://doi.org/10.1021/nl5026419

19. Wu, B. B., Lan, T., Lu, D. N.*, & Liu, Z.* (2014). Ecological and enzymatic responses to petroleum contamination. Environmental Science-Processes & Impacts, 16(6), 1501-1509.

20. Wang, R., Zhang, Y. F., Huang, J. H., Lu, D. N., Ge, J.*, & Liu, Z.* (2013). Substrate imprinted lipase nanogel for one-step synthesis of chloramphenicol palmitate. Green Chemistry, 15(5), 1155-1158. https://doi.org/10.1039/c3gc40465j

21. Zhu, J. Y., Zhang, Y. F., Lu, D. N., Zare, R. N., Ge, J.*, & Liu, Z.* (2013). Temperature-responsive enzyme-polymer nanoconjugates with enhanced catalytic activities in organic media. Chemical Communications, 49(54), 6090-6092. https://doi.org/10.1039/c3cc42493f

22. Lin, M., Lu, D., Zhu, J., Yang, C., Zhang, Y., & Liu, Z.* (2012). Magnetic enzyme nanogel (MENG): a universal synthetic route for biocatalysts. Chemical Communications, 48(27), 3315-3317. https://doi.org/10.1039/c2cc30189j

23. Lin, S., Wang, G., Na, Z., Lu, D.*, & Liu, Z.* (2012). Long-root Eichhornia crassipes as a biodegradable adsorbent for aqueous As(III) and As(V). Chemical Engineering Journal, 183, 365-371. https://doi.org/10.1016/j.cej.2012.01.013

24. Lu, D., Yang, C., & Liu, Z.* (2012). How Hydrophobicity and the Glycosylation Site of Glycans Affect Protein Folding and Stability: A Molecular Dynamics Simulation. Journal of Physical Chemistry B, 116(1), 390-400. https://doi.org/10.1021/jp203926r

25. Sen, L., Diannan, L.*, & Zheng, L.* (2012). Removal of arsenic contaminants with magnetic y-Fe2O3nanoparticles. Chemical Engineering Journal, 211-212, 46-52. https://doi.org/10.1016/j.cej.2012.09.018

26. Xu, D., Tonggu, L., Bao, X., Lu, D.*, & Liu, Z.* (2012). Activation and stabilization of a lipase nanogel using GMA for acryloylation. Soft Matter, 8(6), 2036-2042. https://doi.org/10.1039/c1sm06853a

27. Liu, Z. X., Lu, D. N., Yin, L., Li, J. M., Cui, Y. C., Chen, W.*, & Liu, Z.* (2011). Strengthening the Stability of a Tunnel-Shaped Homotetramer Protein with Nanogels. Journal of Physical Chemistry B, 115(28), 8875-8882. https://doi.org/10.1021/jp108941f

28. Wu, Z. J., Dong, H. J., Zou, L. D., Lu, D. N., & Liu, Z.* (2011). Enriched Microbial Community in Bioaugmentation of Petroleum-Contaminated Soil in the Presence of Wheat Straw. Applied Biochemistry and Biotechnology, 164(7), 1071-1082. https://doi.org/10.1007/s12010-011-9195-1

29. Yang, C., Lu, D. N., & Liu, Z.* (2011). How PEGylation Enhances the Stability and Potency of Insulin: A Molecular Dynamics Simulation. Biochemistry, 50(13), 2585-2593. https://doi.org/10.1021/bi101926u

30. Zhu, B. B., Lu, D. N., Ge, J., & Liu, Z.* (2011). Uniform polymer-protein conjugate by aqueous AGET ATRP using protein as a macroinitiator. Acta Biomaterialia, 7(5), 2131-2138.

● 学术荣誉与奖励

2016年 宝钢全国优秀教师特等奖提名奖

2008年 全国优秀博士论文指导教师

2007年 国务院政府特殊津贴

2004年 教育部新世纪优秀人才计划

2004年 北京市优秀教师

2002年 高等学校优秀骨干教师