主要从事材料、化学品及生物医药的绿色生物制造，结合蛋白质工程、代谢工程及合成生物学等交叉领域的前沿技术，综合利用工程学、生物学、化学和计算机科学等多学科交叉手段来研究酶及细胞催化过程中的重要基础科学问题及工业化应用技术。发展了非天然途径设计、新功能酶的挖掘与改造、原子经济的产品设计工程等系列新方法，成功应用于氨基酸及衍生物、生物基二元醇、精细化学品等重要产品的工业化生产。

●  教育与工作经历

2001-2005  清华大学化工系，学士

2005-2008  清华大学化工系/东京工业大学生命理工学院，硕士

2008-2012  德国汉堡工业大学，博士

2012-2013  德国汉堡工业大学，博士后

2013-2017  清华大学化工系，助理教授

2017-至今   清华大学化工系，副教授

●  研究领域

代谢工程、合成生物学、蛋白质工程

●  开设课程

《化工英语》本科生课程

《代谢工程》研究生课程

●  主要学术任职

Frontiers in Bioengineering and Biotechnology    编委

第三届全国发酵工程技术工作委员会  委员

中国化工学会精细化工专业委员会  青年委员

●  代表性论文

1. Zhong W, Zhang Y, Wu W, Liu D, Chen Z*. Metabolic engineering of a homoserine-derived non-natural pathway for the de novo production of 1, 3-propanediol from glucose. ACS Synth. Biol. 2019, 8（3）：587-595.

2. Wu W, Zhang Y, Liu D, Chen Z*. Efficient mining of natural NADH-utilizing dehydrogenases enables systematic cofactor engineering of lysine synthesis pathway of Corynebacterium glutamicum. Metab. Eng. 2019, 52, 77–86.

3. Wu W, Zhang Y, Huang J, Wu Y, Liu D, Chen Z*. Discovery of a Potentially New Subfamily of ELFV Dehydrogenases Effective for l‐Arginine Deamination by Enzyme Mining. Biotechnol J.  2018, 13 (2), 1700305.

4. Zhang Y, Liu D, Chen Z*.  Production of C2–C4 diols from renewable bioresources: new metabolic pathways and metabolic engineering strategies. Biotechnology for Biofuels 2017, 10, 299.

5. Huang J, Wu Y, Zhang Y, Wu W, Liu D, Chen Z*. Cofactor recycling for co-production of 1,3-propanediol and glutamate by metabolically engineered Corynebacterium glutamicum. Scientific reports 2017, 7, 42246.

6. Chen, Z.*, Huang, J., Wu, Y., Wu, W., Zhang, Y. & Liu, D. Metabolic engineering of Corynebacterium glutamicum for the production of 3-hydroxypropionic acid from glucose and xylose. Metab. Eng. 2017, 39, 151–158.

7. Chen Z*, Huang J, Wu Y, Liu DH. Metabolic engineering of Corynebacterium glutamicum for the de novo production of ethylene glycol from glucose. Metab. Eng. 2016, 33, 12-18.

8. Chen Z, Zeng AP*. Protein engineering approaches to chemical biotechnology. Current Opinion in Biotechnology, 2016, 42, 198-205.

9. Chen Z*, Liu DH. Toward glycerol biorefinery: metabolic engineering for the production of biofuels and chemicals from glycerol. Biotechnology for Biofuels 2016, 9 (1), 205.

10. Chen Z, Geng F, Zeng AP. Protein design and engineering of a de novo pathway for microbial production of 1, 3‐propanediol from glucose. Biotechnol J. 2015, 10（2）：284-289.

11. Bommareddy RR, Chen Z, Rappert S, Zeng AP. A de novo NADPH generation pathway for improving lysine production of Corynebacterium glutamicum by rational design of the coenzyme specificity of glyceraldehyde 3-phosphate dehydrogenase. Metab Eng. 2014, 25:30-37.

12. Chen Z， Rappert S， Zeng AP. 2015. Rational Design of Allosteric Regulation of Homoserine Dehydrogenase by a Non-Natural Inhibitor L-Lysine. ACS Synth. Biol. 4（2）：126-131.

13. Chen Z， Bommareddy R, Frank D, Rappert S， Zeng AP. 2014. Deregulation of Feedback Inhibition of Phosphoenolpyruvate Carboxylase for Improved Lysine Production in Corynebacterium glutamicum. Appl Environ Microbiol 2014, 80：1388-1393.

14. Chen Z, Meyer WQ, Rappert S, Sun JB, Zeng AP. 2011. Coevolutionary analysis enabled rational deregulation of allosteric enzyme inhibition in Corynebacterium glutamicum for lysine production. Appl Environ Microbiol 2011, 77:4352-4360.

15. Chen, Z., Wilmanns, M. & Zeng, A. P. Structural synthetic biotechnology: From molecular structure to predictable design for industrial strain development. Trends in Biotechnol 2010, 28, 534–542.