卢元课题组研究的中心模式是利用工程学、生物学、化学、物理学、数学和计算机科学等多学科交叉手段操作生物大分子和复杂的生物网络。研究的焦点在于发展和应用世界最前沿的技术，突破天然生命体系的限制，快速改造生物分子机器、细胞和系统网络，以解决生物制造、人类健康等领域最具挑战性的工程难题。目前在PNAS、Small、ACS Synthetic Biology, Biotechnology for Biofuels、Bioresource Technology、Biotechnology and Bioengineering等杂志上已发表约60篇高影响学术杂志论文，相关科研工作被化学、生物学、医学、工程学多个研究领域广泛引用；同时被众多科学媒体如ScienceDaily、Phys.org、Reddit、FierceBiotech Research、RT Magazine和GEN News等广泛报导。同时也已发表40多篇国际国内会议论文，拥有5项国际授权专利、13项国内授权专利。参加的科研项目受到了重大项目机构的支持，包括我国973、863、自然科学基金、科技部重大专项，美国的NIH和GCEP基金，日本的文部科学省TSBMI项目基金等。

●  实验室主页

http://LuGroup.net/

●  教育与工作经历

2000~2004     清华大学化学工程系    本科

2004~2009     清华大学化学工程系    博士

2009~2010     美国约翰霍普金斯大学  博士后

2010~2014     美国斯坦福大学        博士后

2014~2016     日本东京大学          特任研究员

2016~2019     清华大学化学工程系    PI/助理教授

2019~至今      清华大学化学工程系    PI/副教授

●  研究领域

无细胞合成生物学；生物大分子工程；生物传感；人工细胞；微纳机器人

●  开设课程

本科生《生物化学原理》

●  主要学术任职

《Frontiers in Bioengineering and Biotechnology》期刊，副主编

《Biotechnology Notes》期刊，编委

《合成生物学》期刊，编委

●  代表性论文/专利/著作

1.Chen Wang#,  Yuhao Geng#,  Qi Sun#,  Jianhong Xu*,  Yuan Lu*. A sustainable and efficient artificial microgel system: Toward creating a configurable synthetic cell. Small, 2020: 2002313.

2.Junzhu Yang, Yuan Lu*. Physical stimuli-responsive cell-free protein synthesis. Synthetic and Systems Biotechnology, 2020, 5(4):363-368.

3.Eunhee Cho, Yuan Lu*. Compartmentalizing cell-free systems: Toward creating life-like artificial cells and beyond. ACS Synthetic Biology, 2020. (Front Cover Article)

4.Peng Zhang#, Junzhu Yang#, Eunhee Cho#, Yuan Lu*. Bringing light into cell-free expression. ACS Synthetic Biology, 2020, 9: 2144-2153. (Cover Article)

5.Liyuan Zhang, Wei Guo*, Yuan Lu*. Advances in cell-free biosensors: Principle, mechanism, and applications. Biotechnology Journal, 2020, 2000187 (Front Cover Article)

6.Xinjie Chen#, Qi Sun#, Yuan Lu*. Creating a locally crowded environment with nanoclay hydrogels for cell-free biosynthesis. Soft Matter, 2020, 16: 5132-5138. (Cover Article)

7.Xiaomei Lin#, Caijin Zhou#, Jisong Zhang*, Yuan Lu*. O2-tuned protein synthesis machinery in Escherichia coli-based cell-free system. Frontiers in Bioengineering and Biotechnology, 2020, 8: Article 312

8.Caijin Zhou#, Xiaomei Lin#, Yuan Lu*, Jisong Zhang*. Flexible on-demand cell-free protein synthesis platform based on a tube-in-tube reactor. Reaction Chemistry & Engineering, 2020, 5: 270-277 (Front Cover Article)

9.Licheng Wang, Hanyi Hou, Xinqi Jiao, Tianyin Shen, Yingying Liu, Yida Qiao, Yu Liu, Yuan Lu*, Jun Ge*. Bifunctional therapy by zinc-cobalt bimetal-organic framework with Encapsulated doxorubicin to overcome drug-resistance. ChemNanoMat, 2019, 5: 1531-1539

10.Yuan Lu, Jamin Koo*. O2 sensitivity and H2 production activity of hydrogenases-A review. Biotechnology and Bioengineering, 2019, 116: 3124-3135

11.Wei Gao#, Eunhee Cho#, Yingying Liu#, Yuan Lu*. Advances and challenges in cell-free incorporation of unnatural amino acids into proteins. Frontiers in Pharmacology, 2019, 10, Article 611

12.Xuanwei Ding#, Dong Liu#, George Booth, Wei Gao, Yuan Lu*. Virus-like particle engineering: From rational design to versatile applications. Biotechnology Journal, 2018, 13(5):1700324 (Front Cover Article)

13.Yan Wu, Yaqiao Hao, Xuan Wei, Qi Shen, Xuanwei Ding, Liyan Wang, Hongxin Zhao*, Yuan Lu*. Impairment of NADH dehydrogenase and regulation of anaerobic metabolism by the small RNA RyhB and NadE for improved biohydrogen production in Enterobacter aerogenes. Biotechnology for Biofuels, 2017, 10: 248

14.Yuan Lu*. Cell-free synthetic biology: Engineering in an open world. Synthetic and Systems Biotechnology, 2017, 2 (1): 23-27

15.Yuan Lu#, Hongxin Zhao#, Chong Zhang, Xin-Hui Xing*. Insights into the global regulation of anaerobic metabolism for improved biohydrogen production. Bioresource Technology, 2016, 200: 35-41

16.Yuan Lu, Wei Chan, Benjamin Y. Ko, Christopher C. VanLang, James R. Swartz*. Assessing sequence plasticity of a virus-like nanoparticle by evolution toward a versatile scaffold for vaccines and drug delivery. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2015, 112(40): 12360-12365 (Direct submission)

17.Hongxin Zhao#, Yuan Lu#, Liyan Wang, Chong Zhang, Cheng Yang, Xin-Hui Xing*. Disruption of lactate dehydrogenase and alcohol dehydrogenase for increased hydrogen production and its effect on metabolic flux in Enterobacter aerogenes. Bioresource Technology, 2015, 194: 99-107. (#Co-first author)

18.Yuan Lu, John P. Welsh, James R. Swartz*. Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2014, 111(1): 125-130 (Direct submission)

19.Yuan Lu, John P. Welsh, Wei Chan, James R. Swartz*. Escherichia coli-based cell free production of flagellin and ordered flagellin display on virus-like particles. Biotechnology and Bioengineering, 2013, 110(8): 2073-2085 (Spotlight article)