长期从事“生物合成PHA材料及其下一代工业生物技术”的研究。在国际学术期刊如Chemical Reviews、Chemical Society Reviews、Science、Advanced Materials, Advanced Science, Nucleic Acids Research、Nature Communications、Trends in Biotechnology、Biomaterials、Metabolic Engineering和Current Opinions in Biotechnology等上共发表微生物技术和生物材料相关论文370多篇， Web of Sciences纪录论文被引用一万九千五百多次(H指数为67)[Google Scholar引用六万多次，H指数大于100]。获得授权专利40项，50个公开专利。开发的技术已经在数家公司用于大规模生产微生物塑料聚羟基脂肪酸酯PHA，使我国成为PHA领域国际上学术和产业最发达的国家、以及其医学应用研究做多的国家。

● 教育与工作经历

1981-1985 广州华南理工大学，学士

1986-1989 奥地利格拉茨工业大学，博士

1990-1992 英国诺丁汉大学，博士后

1992-1994 加拿大阿尔伯达大学，博士后

1994-1997 清华大学生命科学学院，副教授

1997- 至今 清华大学生命科学学院，教授、博导

● 研究领域

合成生物学、微生物代谢工程、生物材料、工业生物技术。

● 开设课程及编写教材

本科生《工业生物技术》

本科生《微生物学(英文) 》

研究生《生物工程前沿》

研究生《合成生物学》

● 主要学术任职

2007年~至今 《生物工程学报》副主编

2020年~至今 《合成生物学》副主编

2007年~至今 《Journal of Biotechnology》副主编

2010年~至今 《Microbial Cell Factories》副主编

2009年~至今 《Biotechnology Journal》副主编

2016年~至今 《Synthetic and Systems Biotechnology》副主编

2020年~至今 《Trends in Biotechnology》编委

2010年~至今 《Current Opinions in Biotechnology》编委

2016年~至今 《Metabolic Engineering》编委

2011年~至今 《ACS Synthetic Biology》编委

2016年~至今 《Microbial Biotechnology》编委

2005年~至今 《Applied Microbiology and Biotechnology》编委

2007年~至今 《Biomaterials》编委

2013年~至今 《Biomacromolecules》编委

2008年~至今 《Artificial Cells, Nanomedicine and Biotechnology》编委

2016年~至今 《Advanced Biosystems》编委

2016年~至今 《Synthetic Biology》编委

2018年~至今 《Metabolic Engineering Communications》编委

● 代表性论文/专利/著作

1. Fang Yang, Huan Wang, Cuihuan Zhao, Lizhan Zhang, Xu Liu, Helen Park, Yiping Yuan, Jian-Wen Ye, Qiong Wu, Chen Guo-Qiang. Metabolic Engineering of Halomonas bluephagenesis for Production of Five Carbon Molecular Chemicals Derived from L-Lysine. Metabolic Engineering 81 (2024) 227-237 doi.org/10.1016/j.ymben.2023.12.001

2. Yueyuan Ma, Jian-Wen Ye, Yina Lin, Xueqing Yi, Xuan Wang, Huan Wang, Ruiyan Huang, Fuqing Wu, Qiong Wu, Xu Liu, Chen Guo-Qiang. Flux optimization using multiple promoters in Halomonas bluephagenesis as a model chassis of the next generation industrial biotechnology. Metabolic Engineering 81 (2023) 249-261 https://doi.org/10.1016/j.ymben.2023.12.011

3. Jing Zhang, Xu Yan, Helen Park, Nigel Scrutton, Tao Chen, Chen Guo-Qiang. Non-Sterile Microbial Production of Chemicals based on Halomonas spp. Current Opinion in Biotechnology 85 (2024) 103064 (COBIOT-D-23-00049R2 Accepted on Dec 30/2023)

4. Helen Park, Hongtao He, Xu Yan, Xu Liu, Nigel S. Scrutton, Chen Guo-Qiang. PHA is not just a bioplastic! Biotechnology Advances 71 (2024) 108320 https://doi.org/10.1016/j.biotechadv.2024.108320

5. Qitiao Hu, Simian Sun, Zhongnan Zhang, Wei Liu, Xueqing Yi, Hongtao He, Nigel S. Scrutton, Guo-Qiang Chen. Ectoine Hyperproduction by Engineered Halomonas bluephagenesis. Metabolic Engineering 82 (2024) 238-249 https://doi.org/10.1016/j.ymben.2024.02.010 (2024)

6. Shuang Zheng, Xu Yan, Peng Jiang, Zonghao Zhang, Jiale Wang, Yifei Zheng, Kang Ren, Lizhan Zhang, Xu Liu, Chen Guo-Qiang. A self-stimulating mechanism based on a polyhydroxyalkanoates biosensor and its applications for Halomonas. Chemical Engineering Journal 498 (2024) 151413 https://doi.org/10.1016/j.cej.2024.151413

7. Zhang Lizhan, Ye Jian-Wen, Li Gang, Park Helen, Luo Hao, Lin Yina, Li Shaowei, Yang Weinan, Guan Yuying, Wu Fuqing, Huang Wuzhe, Wu Qiong, Scrutton Nigel S, Nielsen Jens, Chen Guo-Qiang. A Long-Term Growth Stable Halomonas sp. Deleted with Multiple Transposases Guided by Its Metabolic Network Model Halo-ecGEM. Metabolic Engineering 84 (2024) 95–108, DOI: 10.1016/j.ymben.2024.06.004 (2024)

8. Helen Park, Lizhan Zhang, Hongtao He, Xu Yan, Nigel Scrutton, Chen Guo-Qiang. Engineering EPS in Halomonas bluephagenesis leads to self-flocculation and filamentation for convenient downstream processing. Chemical Engineering Journal 495 (2024) 153374 doi.org/10.1016/j.cej.2024.153374

9. Chen Fanfan, Zhao Zifan, Liu Xinyi, Chen Hu, An Lihua, Wang Yuan, Xu Weisi, Guo Suli, Jiang Songlun, Chen Guo-Qiang, Sun Yuchun Sun, Zhang Xu. A multifunctional microneedle patch loading exosomes and magnetic nanoparticles synergistically for treating oral mucosal lesions. Applied Materials Today 40 (2024) 102382 https://doi.org/10.1016/j.apmt.2024.102382

10. Ge Zhang, Weike Guo, Xueqing Yi, Zhongnan Zhang, Lizhan Zhang, Xu Liu, Fuqing Wu, Qiong Wu, Guo-Qiang Chen. Engineered Halomonas for Production of g-Aminobutyric Acid and Butyrolactam, Bioresource Technology 413 (2024) 131448 https://doi.org/10.1016/j.biortech.2024.131448

11. Jian Li (李健), Xu Zhang (张旭), Zi-Xin Peng, Jian-Hai Chen (陈建海), Jian-Hui Liang (梁建辉), Li-Qing Ke (柯丽青), Dan Huang (黄丹), Wen-Xiang Cheng (成文翔), Sien Lin (林思恩), Gang Li (李刚), Rui Hou (侯蕊), Wen-Zhao Zhong (钟文钊), Zheng-Jie Lin (林正捷), Ling Qin (秦岭), Guo-Qiang Chen (陈国强),*, and Peng Zhang (张鹏)*. Metabolically activated energetic materials mediate cellular anabolism for bone regeneration. Trends in Biotechnology 2538 (2024) 1-31 https://doi.org/10.1016/j.tibtech.2024.08.002

12. Zhongnan Zhang, Mingwei Shao, Ge Zhang, Simian Sun, Xueqing Yi, Zonghao Zhang, Hongtao He, Kang Wang, Qitiao Hu, Qiong Wu and Chen Guo-Qiang. Engineering Halomonas bluephagenesis for Synthesis of Polyhydroxybutyrate (PHB) in the Presence of High Nitrogen Containing Media. Metabolic Engineering 86 (2024) 242-249 https://doi.org/10.1016/j.ymben.2024.10.012

13. Yiling Chen, Xu Liu, Lizhan Zhang Jishuai Yang, Weike Guo, Shuang Zheng, Jiale Wang, Fuqing Wu, Xu Yan, Qiong Wu, Chen Guo-Qiang. Cell Sizes Matter for Industrial Bioproduction, A Case of Polyhydroxybutyrate. Advanced Science 2025, 2412256 DOI: 10.1002/advs.202412256

14. Zonghao Zhang, Shuang Zheng, Zhongnan Zhang, Fuqing Wu, Qiong Wu, Chen Guo-Qiang. Lactose Induced Bioproduction by Halomonas Grown under Open Conditions. Chemical Engineering Journal 507 (2025) 160468 https://doi.org/10.1016/j.cej.2025.160468

15. Shuang Zheng, Mingwei Shao, Wanze Wang, Chen Guo-Qiang. Next-generation biotechnology inspired by extremes. EMBO Reports. Science & Society section 27 (2025) 1-5 DOI:10.1038/s44319-025-00389-6

16. Zheng Shuang; Zhao Cuihuan; Chen Yuemeng, Zhang Zonghao, He Yuhan, Wang Jiale, He Hongtao, Chen Guo-Qiang. Engineered Vibrio natriegens with Toxin-Antitoxin System for High-Productivity Biotransformation of L-Lysine to Cadaverine. Journal of Agricultural and Food Chemistry (2025) https://doi.org/10.1021/acs.jafc.4c12616

17. Huan Wang, Yunyun Ouyang, Weinan Yang, Hongtao He, Jiangnan Chen, Yiping Yuan, Helen Park, Fuqing Wu, Fang Yang*, Chen GQ*. Production and Characterization of Copolymers Consisting of 3-Hydroxybutyrate and Increased 3-Hydroxyvalerate by β-Oxidation Weakened Halomonas. Metabolic Engineering 89 (2025) 97-107 doi.org/10.1016/j.ymben.2025.02.009

18. Yiping Yuan，Huan Wang，Hongtao He，Zhongnan Zhang，Fang Yang， Yiling Chen, Fuqing Wu, Qiong Wu, Chen Guo-Qiang. Polyhydroxyalkanoate Production by Engineered Halomonas Grown in Lignocellulose Hydrolysate. Bioresource Technology 425 (2025) 132313 doi.org/10.1016/j.biortech.2025.132313

19. Xu Yan, Jiale Wang, Rou Wen, Xinyu Chen and Guo-Qiang Chen. The Halo of Future Bio-industry based on Engineering Halomonas. Metabolic Engineering 90 (2025) 16-32 doi.org/10.1016/j.ymben.2025.03.001

20. Hongtao He, Ng Wuh Jer, Qitiao Hu, Zhongnan Zhang, Simian Sun, Geyuan Xu, Shimao Yang, Shuang Zheng, Xu Liu, Qiong Wu*, Chen GQ*. Engineering Halomonas bluephagenesis for Pilot Production of Terpolymers (3-Hydroxybutyrate, 4-Hydroxybutyrate and 3-Hydroxyvalerate) from Glucose. Metabolic Engineering 90 (2025) 117-128 https://doi.org/10.1016/j.ymben.2025.03.003

21. Xu Liu, Helen Park, Yannic Sebastian Ackermann, Luc Avérous, Hendrik Ballerstedt, Werner Besenmatter, Blas Blázquez, Uwe T. Bornscheuer, Yannick Branson, William Casey, Víctor de Lorenzo, Weiliang Dong, Tilman Floehr, Manuel S. Godoy, Yu Ji, Andreas Jupke, Jürgen Klankermayer, David San León, Luo Liu, Xianrui Liu, Yizhi Liu, Maria T. Manoli, Esteban Martínez-García, Tanja Narancic, Juan Nogales, Kevin O’Connor, Ole Osterthun, Rémi Perrin, M. Auxiliadora Prieto, Eric Pollet, Alexandru Sarbu, Ulrich Schwaneberg, Haijia Su, Zequn Tang, Till Tiso, Zishuai Wang, Ren Wei, Gina Welsing, Nick Wierckx, Birger Wolter, Gang Xiao, Jianmin Xing, Yilin Zhao, Jie Zhou, Tianwei Tan, Lars M. Blank, Min Jiang, Guo-Qiang Chen. Exploring biotechnology for plastic recycling，degradation, and upcycling for a sustainable future. Biotechnology Advances 81 (2025) 108544 doi.org/10.1016/j.biotechadv.2025.108544

● 学术荣誉与奖励

国际生物聚酯工业奖（2024）

国际代谢工程奖（2023）

自然资源科学技术二等奖（2022）

全国先进科技工作者（2016）

候德傍化工创新奖（2015）

首届闵恩泽能源化工杰出贡献奖（2013）

谈家祯生命科学创新奖（2011）

教育部长江学者特聘教授（2004）

教育部高校青年教师奖（2004）

第八届中国青年科技奖（2003）

纽伦堡国际发明奖（2003）

茅以升科技奖（2003）

自然科学基金委国家杰出青年（2002）

国家发明二等奖(排名第一)（2002）

973“合成生物学”项目以及国家重大专项项目的首席科学家

清华大学合成与系统生物学中心主任

曾连续6年获得清华大学学生“良师益友”的光荣称号，进入清华大学“良师益友”名人堂

连续8年获得清华大学高论文他引的“梅贻琦奖”

连续十年获得Elsevier出版社生化与分子生物学高引用作者