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戈钧    教授


电话:010-62780775
地址:清华大学英士楼
邮件:junge@tsinghua.edu.cn



从事生物化工领域研究工作。针对生物制造、生物医药、生物安全、生物检测等对关键生物催化技术的需求,开展酶催化剂工程、生物-化学复合催化等研究。先后获得863青年科学家专题(2014)、国家优秀青年科学基金项目(2016)、国家重点研发计划青年项目(2016,项目首席)、北京市杰出青年科学基金项目(2018)等资助;发表论文60余篇,引用6000余次,授权发明专利10项。2015年入选麻省理工《技术评论》(MIT Technology Review)评选的全球35位35岁以下创新人物,2017年获得闵恩泽能源化工青年进步奖。近年来成果以第一/通讯作者论文发表于Nature Catalysis,Nature Nanotechnology,Nature Communications, Science Advances等期刊。

●  教育与工作经历

2000~2004     清华大学化学工程系   本科

2004~2009     清华大学化学工程系   博士

2009~2012        斯坦福大学化学系   博士后

2012         清华大学化学工程系   讲师

2012~2020     清华大学化学工程系   副教授

2020~至今      清华大学化学工程系   教授

●  研究领域

生物化工;生物催化;酶-金属复合催化;生物医药;生物检测

●  开设课程及编写教材

本科生《生物化学原理》

研究生《纳米生物技术》

●  主要学术任职

2012年~至今   中国颗粒学会  青年理事

2014年~至今   中国颗粒学会  生物颗粒专业委员会委员

2017年~至今    中国化工学会生物化工专业委员会青年学者工作委员会常务委员

2016年~至今   Applied Biochemistry and Biotechnology  Editorial Board

2019年~至今   Bioresources and Bioprocessing  Editorial Board

2020年~至今   Chinese Journal of Chemical Engineering  Youth Editorial Committee  Section Editor

2020年~至今   Chinese Journal of Catalysis  Associate Editor

●  代表性论文/专利/著作

1.Cao, Y.; Li, X.; Ge, J.* Enzyme catalyst engineering toward the integration of biocatalysis and chemocatalysis. Trends Biotechnol. 2021, doi.org/10.1016/j.tibtech.2021.01.002

2.Cao, Y.; Ge, J.* Study of specific receptor binding mode suggests a possible enzymatic disinfectant for SARS-CoV-2. Langmuir 2021, 37, 1707-1713.

3.Li, X.; Cao, X.; Xiong, J.; Ge, J.* Enzyme-metal hybrid catalysts for chemoenzymatic reactions. Small 2020, 16, 1902751.

4.Hu, C.#; Bai, Y.#; Hou, M.; Wang, Y.; Wang, L.; Cao, X.; Chan, C.-W.; Sun, H.; Li, W.; Ge, J.*; Ren, K.*. Defect-induced activity enhancement of enzyme-encapsulated metal-organic frameworks revealed in microfluidic gradient mixing synthesis. Sci. Adv. 2020, 6, eaax5785.

5.Wu, X.#; Yue, H.#; Zhang, Y.#; Gao, X.; Li, X.; Wang, L.; Cao, Y.; Hou, M.; An, H.; Gu, H.; Zhang, L.*; Li, S.*; Lou, W.; Ma, J.; Lin, H.; Fu, Y.; Wei, W.*; Zare, R. N.; Ge, J.* Packaging and delivering enzymes by amorphous metal-organic frameworks. Nat. Commun. 2019, 10, 5165.

6.Li, X.#; Cao, Y.#; Luo, K.#; Sun, Y.; Xiong, J.; Wang, L.; Liu, Z.; Li, J.; Ma, J.; Ge, J. *; Xiao, H. *; Zare, R. N. * Highly active enzyme-metal nanohybrids synthesized in protein-polymer conjugates. Nat. Catal. 2019, 2, 718-725.

7.Cao, Y.#; Li, X.#; Xiong, J.; Wang, L.; Yan, L.*; Ge, J.* Investigating the origin of high efficiency in confined multienzyme catalysis. Nanoscale, 2019, 11, 22108-22117.

8.Zhang, C.; Wang, X.; Hou, M.; Li, X.; Wu, X.; Ge, J.* Immobilization on metal-organic framework engenders high sensitivity for enzymatic electrochemical detection. ACS Applied Materials & Interfaces 2017, 9, 13831-13836.

9.Wu, X.#; Ou, G.#; Yang, C.; Ge, J.*, Wu, H.* Enhanced enzymatic reactions by solar-to-thermal conversion nanoparticles. Chemical Communications 2017, 53, 5048-5051.

10.Zhang, Y.; Ge, J.*; Liu, Z.* Enhanced activity of immobilized or chemically modified enzymes. ACS Catalysis 2015, 5, 4503-4513.

11.Wu, X.; Hou, M.; Ge, J.* Metal-organic frameworks and inorganic nanoflowers: a type of emerging inorganic crystal nanocarriers for enzyme immobilization. Catalysis Science & Technology 2015, 5, 5077-5085.

12.Wu, X.; Yang, C.; Ge, J.*; Liu, Z. Polydopamine tethered enzyme/metal-organic framework composites with high stability and reusability. Nanoscale 2015, 7, 18883-18886.

13.Wu, X.; Ge, J.*; Yang C.; Hou, M.; Liu, Z. Facile synthesis of multiple enzyme-containing metal-organic frameworks in a biomolecule-friendly environment. Chemical Communications 2015, 51, 13408-13411.

14.Lyu, F.; Zhang, Y.; Zare, R. N.; Ge, J.*; Liu, Z.* One-pot synthesis of protein-embedded metal-organic frameworks with enhanced biological activities. Nano Lett. 2014, 14, 5761-5765.

15.Ge, J.#; Neofytou, E.#; Lei, J.; Beygui, R. E.; Zare, R. N.* Protein-polymer hybrid nanoparticles for drug delivery. Small 2012, 8, 3573-3578.

16.Ge, J. #; Neofytou, E. #; Cahill, III, T. J.; Beygui, R. E.; Zare, R. N.* Drug release from electric-field-responsive nanoparticles. ACS Nano 2012, 6, 227-233.

17.Ge, J.#; Lei, J.#; Zare, R. N.* Protein-inorganic hybrid nanoflowers. Nat. Nanotech. 2012, 7, 428-432.

18.Ge, J.; Lei, J. D.; Zare, R. N.* Bovine serum albumin-poly(methyl methacrylate) nanoparticles: an example of frustrated phase separation. Nano Letters 2011, 11, 2551-2554.

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Email:chemeng@tsinghua.edu.cn

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